期刊论文

中文

中国妇幼保健

1001-4411

2008

23

36

5191-5193

10.3969/j.issn.1001-4411.2008.36.047

湖南省科技计划重点资助项目（项目编号:2007FJ2005）；

本校为第一机构

目的:检测正常妊娠小鼠与反复自然流产小鼠母胎界面SOCS1、SOCS2、SOCS3蛋白表达的差异。方法:建立反复自然流产小鼠模型CBA/J×DBA/2及正常妊娠小鼠模型CBA/J×BALB/c,取孕14.5天的蜕膜和胎盘组织,Western blot法检测SOCS1、SOCS2、SOCS3蛋白的表达。结果:与正常妊娠模型组相比,反复自然流产模型组小鼠母胎界面SOCS1蛋白表达非常显著升高（P

Objective： To detect the different expression of the protein expression of SOCS1, SOCS2, SOCS3 in maternal - fetal interface of mice with normal pregnancy and recurrent spontaneous abortion （RSA） . Methods： CBA/J × BALB/C and CBA/J × DBA/2 were used as normal pregnancy and RSA model respeetively. The protein expressions of SOCS1, SOCS2 and SOCS3 in decidual and placental tissues on day 14. 5 of gestation were detected by Western blotting. Results ： Compared with normal pregnancy model mice, the expression of SOCS1 was significantly incre...