期刊论文

中文

中国医药导报

1673-7210

2010

07

36

30-31,51

10.3969/j.issn.1673-7210.2010.36.013

湖南省教育厅基金资助（项目编号:08C643）； 2009年度湖南省大学生创新性试验计划；

本校为第一机构

目的:建立合成羟丙基-β-环糊精的方法.方法:以β-环糊精为原料,在NaOH催化下,分别以环氧丙烷(C3H6O)和环氧氯丙烷为缩合剂合成羟丙基-β-环糊精;并研究了缩合剂、反应时间、反应温度及氢氧化钠浓度对产率的影响. 结果:以环氧丙烷为缩合剂,当反应物配料比为n(NaOH)∶n(β-CD)∶n(C3H6O)为10∶1∶10,30℃下反应24 h,可以获得37%的收率,羟丙基-β-环糊精的平均取代度为2.82.结论:以环氧丙烷为缩合剂能较高产率地合成羟丙基-β-环糊精.

Objective： To study the synthesis and characterization of Hydroxypropyl-β-Cyclodextrin.Methods： Used sodium hydroxide as catalyst,hydroxypropyl-β-cyclodextrin was synthesized through the reaction between β-Cyclodextrin and propylene oxide or propylene oxychloride respectively.The influence of condensetion reagent,the reaction time,temperature and the density of NaOH on the yield was discussed.Results： The propylene oxide was the best condensation reagent.The hydroxypropyl-β-cyclodextrin was synthesized with 37% yield when molar ratio of ...