期刊论文

中文

中国医药导报

1673-7210

2011

8

2

29-30

10.3969/j.issn.1673-7210.2011.02.012

湖南省教育厅项目（项目编号:08C643）； 2009年度湖南省大学生创新性实验计划；

本校为第一机构

目的:优化合成3,4,5-三甲氧基氯苄的方法.方法:以四氢呋喃为溶剂,3,4,5-三甲氧基苯甲酸在ZnCl/NaBH还原体系中制备3,4,5-三甲氧基苄醇,并经正交设计优化合成工艺研究,醇经氯化反应得到3,4,5-三甲氧基氯苄.结果:经过IR、

Objective： To study a good method of synthesize 3,4,5-trimethoxylbenzyl chloride.Methods： Used THF as solvent and 3,4,5-trimethoxylbenzene carbonic acid as the raw material,the 3,4,5-trimethoxylbenzyl chloride was prepared by an reduction action in ZnCl2/NaBH4 system,the acid translated into 3,4,5-trimethoxylbenzalcohol,and then by chlorination,the alcohol changed into 3,4,5-trimethoxylbenzyl chloride.Results： The target production was determined by IR and 1H-NMR spectrum.Conclusion： The 3,4,5-trimethoxylbenzyl chloride can b...