期刊论文

中文

中国医药导报

1673-7210

2018

15

7

9-11+15+181

国家自然科学基金项目（81273816）； 广东省清远市科技计划项目（2016A020）；

本校为第一机构

目的 探讨壮骨止痛方对去卵巢骨质疏松大鼠血清降钙素基因相关肽(CGRP)及骨组织β1-AR表达的影响.方法 72只SPF级雌性SD大鼠随机选出12只,摘除卵巢周围相应质量脂肪后作为假手术组.其余60只采用双侧去卵巢法制备骨质疏松病理模型,随机分为模型组、壮骨止痛方高剂量组(13.2 g/kg)、中剂量组(6.6 g/kg)、低剂量组(3.3 g/kg)和戊酸雌二醇组(2.1×10-5 g/kg),每组各12只.模型组及假手术组给予等体积纯净水,均干预13周.采用ELISA法检测血清CGRP含量,免疫组化法检测骨组织β2-AR蛋白表达.结果 与假手术组比较,模型组大鼠血清CGRP含量显著减少,骨组织β2-AR蛋白表达显著下调,差异均有高度统计学意义(P＜...

Objective To explore the effect of Zhuanggu Zhitong prescription on the CGRP and β2-AR in ovariec- tomized osteoporosis rats and investigate its mechanism in anti-osteoporosis. Method 72 rats were randomly divided in- to sham operation group （12 cases） and model group （60 cases）, the model group rats were ovariectomized osteoporosis and the sham operation group rats were excised equal weight fat. After the modeling, the rats were randomly divided into model group, Zhuanggu Zhitong prescription high-dose group （13.2 g/kg）, middle-dose gro...