期刊论文

中文

中国医药导报

1673-7210

2019

16

25

53-56

湖南省自然科学基金项目(2018JJ2291)。

本校为第一机构

线粒体以其结构和功能的特殊性广泛存在于高等动植物中。线粒体中含有众多酶系,能通过电子传递链与氧化磷酸化偶联生成三磷酸腺苷,是主要的产能结构。线粒体功能的实现与其结构的变化密不可分。线粒体融合与分裂是是实现功能的基础。线粒体融合能够促进相邻线粒体之间的联系,而线粒体分裂能促使线粒体在细胞内的正常分布,对于维持机体正常生理活动具有重要意义。截至目前,在哺乳动物中做过大量研究的线粒体融合蛋白包括线粒体融合蛋白1、线粒体融合蛋白2,线粒体分裂蛋白包括动力相关蛋白1。若线粒体融合分裂运动失衡,线粒体网络状结构被破坏,细胞色素C等促凋亡因子释放,就会导致细胞凋亡的发生。...

Mitochondria is widely found in higher animals and plants due to their specific structure and function. Mitochondria contains a large number of enzyme systems, which can be coupled to oxidative phosphorylation via an electron transport chain to form adenosine triphosphate, which is the main production structure. The realization of mitochondrial function is inseparable from the changes in its structure. Mitochondrial fusion and division are the basis for achieving function. Mitochondrial fusion can promote the connection between adjacent mitochondria, and mitochondrial division can promote the ...