Effects of cerebral glucose levels in infarct areas on stroke injury mediated by blood glucose changes

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成果类型：

期刊论文

作者：

Zhang, Shuai;Song, Xiu-Yun;Xia, Cong-Yuan;Ai, Qi-Di;Chen, Jiao;...

通讯作者：

Chen, Nai-Hong

作者机构：

[Ai, Qi-Di; Song, Xiu-Yun; He, Wen-Bin; Zhang, Shuai; Chen, Nai-Hong; Xia, Cong-Yuan; Chen, Jiao; Chu, Shi-Feng] Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Xian Nong Tan St 1, Beijing 100050, Peoples R China.

[Ai, Qi-Di; Song, Xiu-Yun; He, Wen-Bin; Zhang, Shuai; Chen, Nai-Hong; Xia, Cong-Yuan; Chen, Jiao; Chu, Shi-Feng] Chinese Acad Med Sci, Peking Union Med Coll, Ctr Neurosci, Xian Nong Tan St 1, Beijing 100050, Peoples R China.

[Ai, Qi-Di; Chen, Nai-Hong; Chu, Shi-Feng] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[He, Wen-Bin; Chen, Nai-Hong] Shanxi Univ Tradit Chinese Med, Taiyuan 030024, Peoples R China.

通讯机构：

[Chen, Nai-Hong] C

[Chen, Nai-Hong] H

[Chen, Nai-Hong] S

Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Xian Nong Tan St 1, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Peking Union Med Coll, Ctr Neurosci, Xian Nong Tan St 1, Beijing 100050, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2016

卷：

期：

页码：

93815-93825

DOI：

10.1039/c6ra19715a

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81274122, 81173578, 81202507, 81373997]; National Mega-project for Innovative Drugs [2012ZX09301002-004, 2012ZX09103101-006, 2012ZX09301002-001]; National High-Tech R&D Programme (863 Program) [2012AA020303]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)Program for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1007]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20121106130001]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7131013, 7142115]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]

机构署名：

本校为通讯机构

摘要：

Admission hyperglycemia is considered to be related to poor outcomes of ischemic stroke. However, there is controversy regarding effects of attempts to lower blood glucose in stroke patients. This study aimed at determining the effects of blood glucose fluctuation on stroke injury by detection of cerebral glucose levels. A single intraperitoneal injection of glucose (0, 0.5, 1, 1.5 or 2 g kg-1) at 5 min before reperfusion caused blood glucose fluctuation (5-15 mmol L-1) lasting for 2 h after reperfusion. Blood glucose levels of 6-10 mmol L-1decreased stroke injury after reperfusion for 24 h an...

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Effects of cerebral glucose levels in infarct areas on stroke injury mediated by blood glucose changes

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