期刊论文

Hu, J.-Z.

中文

现代药物与临床

1674-5515

2022

37

2

252-263

10.7501/j.issn.1674-5515.2022.02.005

湖南省自然科学基金计划资助项目（2018JJ6037）；

本校为第一且通讯机构

目的 运用网络药理学和分子对接的方法研究黄蜀葵花干预糖尿病肾病的多成分、多靶点、多通路作用机制,旨在为其基础研究及临床应用提供依据.方法 通过ETCM、HERB数据库结合文献报道,筛选黄蜀葵花活性成分,并通过PharmMapper数据库预测其潜在靶点,建立靶点数据库.通过Genecards、OMIM、Drugbank、TTD等数据库筛选糖尿病肾病相关靶点,应用R4.1.0软件取两者交集靶点.通过STRING平台获得蛋白互作(PPI)关系,并应用Cytoscape 3.8.2构建PPI网络并分析其中关键靶点.通过David数据库进行基因本体论(GO)和京都基因和基因组百科全书(KEGG)基因富集分析,得到黄蜀葵花干预糖尿病肾病的潜在作用通路,采用Cytos...

Objective Using the methods of network pharmacology and molecular docking, the mechanism of multicomponent, multitarget and multipathway action of flowers of Abelmoschus manihot in the intervention of diabetic kidney disease was studied, aiming to provide basis for its basic research and clinical application. Methods ETCM and HERB database combined with literature reports were used to screen the active ingredients of flowers of Abelmoschus manihot, and PharmMapper database was used to predict its potential targets and establish target database....