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CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer

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成果类型:
期刊论文
作者:
Chen, Xingyu;Xu, Runshi;He, Dong;Zhang, Yao;Chen, Haotian;...
通讯作者:
Cao, Ke
作者机构:
[Chen, Xingyu; Zhu, Yuxing; Cao, Ke; Cheng, YaXin; Liu, Rui; Xiao, Mengqing; Deng, Liping; Chen, Haotian; Gong, Lian; Zhang, Yao; Wang, Zhanwang; Zhu, Rongrong] Cent South Univ, Xiangya Hosp 3, Dept Oncol, 283 Tongzipo Rd, Changsha 410013, Peoples R China.
[Xu, Runshi] Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd,Hanpu Kejiao Pk, Changsha 410208, Peoples R China.
[He, Dong] Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Dept Resp, Changsha 410000, Peoples R China.
通讯机构:
[Cao, Ke] D
Department of Oncology, Third Xiangya Hospital, Central South University, 283 Tongzipo Road, Changsha, 410013, China.
语种:
英文
期刊:
Oncogene
ISSN:
0950-9232
年:
2021
卷:
40
期:
43
页码:
6223-6234
基金类别:
We would like to thank the TCGA, GEO, and TIMER databases for the availability of the data. We would like to thank TissueGnostics Aisa Pacific limited for their technical support, And the help of hongzhe Sun and Xiaojing Liu, the technical engineer. This work was supported by the National Natural Science Foundation of China (81874137), the science and technology innovation Program of Hunan Province (2020RC4011), the Outstanding Youth Foundation of Hunan Province (2018JJ1047), the Hunan Province Science and Technology Talent Promotion Project (2019TJ-Q10), Young Scholars of “Furong Scholar Program” in Hunan Province(206030106), and the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University (BJ202001).
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Immune-checkpoint blockade (ICB) has been routinely implemented to treat bladder cancer; however, most patients have little or no clinical benefit. In this study, 348 pretreated metastatic urothelial cancer samples from the IMvigor210 cohort were used to identify important genes significantly associated with CD8+ T effector and immune checkpoint signatures. The immune checkpoint inhibitor score (IMS) scoring system was constructed to predict the immunotherapy responsiveness. Transcriptome analysis confirmed that the high IMS score group had significant immune activation with better prognosis a...

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