RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Hao;Cao, Hui;Luo, Hong;Zhang, Nan;Wang, Zeyu;...

通讯作者：

Cheng, Q.;Cheng, Y.

作者机构：

[Cheng, Yuan; Luo, Hong; Liu, Guodong; Zhang, Hao; Xie, Zongyi] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China.

[Cao, Hui] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Peoples R China.

[Cao, Hui] Hunan Univ Chinese Med, Sch Clin Med, Changsha, Peoples R China.

[Zhang, Nan] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Peoples R China.

[Wang, Zeyu; Dai, Ziyu; Cheng, Quan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China.

通讯机构：

[Cheng, Y.; Cheng, Q.] D

Department of Neurosurgery, China

语种：

英文

关键词：

CD44;glioma;immunotherapy;PD-L1;RUNX1

期刊：

Frontiers in Immunology

ISSN：

1664-3224

年：

2023

卷：

页码：

1086280

DOI：

10.3389/fimmu.2023.1086280

基金类别：

This study was supported by the Science Foundation of Chongqing (cstc2019jcyj-msxmX0231) and the Chongqing Scientific and Health Joint Medical Research Project (2020GDRC021). Acknowledgments

机构署名：

本校为其他机构

院系归属：

临床医学院

摘要：

Background: Glioma is one of the most common, primary, and lethal adult brain tumors because of its extreme aggressiveness and poor prognosis. Several recent studies relevant to the immune function of CD44, a transmembrane glycoprotein as a significant hyaluronic acid receptor, have achieved great success, revealing the critical role of CD44 in immune infiltration in gliomas. The overexpression of CD44 has been verified to correlate with cancer aggressiveness and migration, while the clinical and immune features of CD44 expression have not yet ...

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RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis

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