STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats

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成果类型：

期刊论文

作者：

Tang, Qing-ping;Shen, Qin;Wu, Li-xiang;Feng, Xiang-ling;Liu, Hui;...

通讯作者：

Liu, Zun-jing

作者机构：

[Tang, Qing-ping] Hunan Univ Chinese Med, Brain Hosp Hunan Prov, Dept Rehabil, Changsha 410007, Hunan, Peoples R China.

[Tang, Qing-ping; Wu, Li-xiang] Cent S Univ, Sch Basic Med Sci, Dept Physiol, Changsha 410078, Hunan, Peoples R China.

[Shen, Qin] Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

[Feng, Xiang-ling; Liu, Hui] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.

[Wu, Bei] Cent S Univ, Xiangya Hosp, Dept Otolaryngol, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Liu, Zun-jing] C

China Japan Friendship Hosp, Dept Neurol, Beijing 100029, Peoples R China.

语种：

英文

关键词：

Motor training;Signal transducer and activator of transcription 3 (STAT3);Brain-derived neurotrophic factor (BDNF);Protein interacting with C kinase 1 (PICK1);Neural plasticity

关键词(中文)：

运动训练;信号传导与转录激活因子3（STAT3）;脑源性神经营养因子（BDNF）;突触素;蛋白激酶Cα相互作用蛋白1（PICK1）;神经可塑性

期刊：

浙江大学学报(英文版)B辑：生物医学与生物技术

ISSN：

1673-1581

年：

2016

卷：

期：

页码：

493-502

DOI：

10.1631/jzus.B1500297

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973167, 81472160, 81173595]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2011M501301, 2012T50711]; China-Japan Friendship Hospital Youth Science and Technology Excellence Project [2014-QNYC-A-04]

机构署名：

本校为第一机构

院系归属：

针灸推拿与康复学院

摘要：

Willed-movement training has been demonstrated to be a promising approach to increase motor performance and neural plasticity in ischemic rats. However, little is known regarding the molecular signals that are involved in neural plasticity following willed-movement training. To investigate the potential signals related to neural plasticity following willed-movement training, littermate rats were randomly assigned into three groups: middle cerebral artery occlusion, environmental modification, and willed-movement training. The infarct volume was measured 18 d after occlusion of the right middle...

摘要(中文)：

调控神经可塑性的STAT3在意向性运动疗法干预后局灶性脑缺血大鼠中的表达目的:探讨意向性运动疗法干预后与神经可塑性相关的信号通路。创新点:首次发现意向性运动疗法干预后信号传导与转录激活因子3(STAT3)表达增高,以及STAT3直接调控神经可塑性相关基因。方法:将大脑中动脉梗死(MCAO)模型大鼠随机分为 MCAO组、环境改变组和意向性运动疗法组。18天后测量三组大鼠的脑梗死面积。应用逆转录聚合酶链反应(RT-PCR)和荧光免疫染色法分别检测STAT3的基因和蛋白的表达;应用染色质免疫共沉淀检测STAT3是否绑定脑源性神经营养因子(BDNF)、突触素以及蛋白激酶Cα相互作用蛋白1(PICK1)。结论:研究结果显示...

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STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats

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