Endoplasmic reticulum stress, an important factor in the development of Parkinson’s disease

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成果类型：

期刊论文

作者：

Mou, Zheng;Yuan, Yu-he;Zhang, Zhao;Song, Lian-kun;Chen, Nai-Hong*

通讯作者：

Chen, Nai-Hong

作者机构：

[Mou, Zheng; Chen, Nai-Hong; Yuan, Yu-he; Song, Lian-kun; Zhang, Zhao] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Mou, Zheng; Chen, Nai-Hong; Yuan, Yu-he; Song, Lian-kun; Zhang, Zhao] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Mou, Zheng; Chen, Nai-Hong; Yuan, Yu-he; Song, Lian-kun; Zhang, Zhao] Peking Union Med Coll, 2 Nanwei Rd, Beijing 100050, Peoples R China.

[Chen, Nai-Hong] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Chen, Nai-Hong] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Chen, Nai-Hong] P

[Chen, Nai-Hong] C

Peking Union Med Coll, 2 Nanwei Rd, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 2 Nanwei Rd, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Compound;Endoplasmic reticulum stress;Hormesis;Neuroinflammation;Parkinson's disease

期刊：

Toxicology Letters

ISSN：

0378-4274

年：

2020

卷：

324

页码：

20-29

DOI：

10.1016/j.toxlet.2020.01.019

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573640, 81773925, 81603316]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7161011]; Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces [2016TP2008, BG201701]; Shandong Province Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2017BH086]; Research Fundation of Qilu Hospital of Shandong University [QDKY2017QN02]

机构署名：

本校为其他机构

摘要：

Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors disturb ER balance and induce the accumulation of misfolded/unfolded proteins, which initiate ER stress and disturb normal cell function. ER stress perturbs Ca2+ homeostasis and initiates the activation of autophagy and inflammasomes,...

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Endoplasmic reticulum stress, an important factor in the development of Parkinson’s disease

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