期刊论文

Zhu, Ying;Xu, Y

英文

Frontiers in Genetics

1664-8021

2023

14

1270085

10.3389/fgene.2023.1270085

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the National Natural Science Foundation of China (81874466, 81904176, and 82374426), the Natural [81874466, 81904176, 82374426]; National Natural Science Foundation of China [2021JJ30531]; Natural Science Foundation of Hunan Province [21B0389]; Scientific Research Foundation of Hunan Provincial Department of Education [2021SK51413, 2021SK51406]; Clinical Medical Technology Innovation Guide Project of Hunan Province [2023CX07]; Innovation Project for Graduate Students of Hunan University of Chinese Medicine

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Background: Endoplasmic reticulum stress (ERS) is an important pathophysiological mechanism in ulcerative colitis (UC) and Crohn's disease (CD). ERS-related genes may be influenced by genetic factors and intestinal inflammation. However, the role of ERS as a trigger or potential etiological factor for UC and CD is unclear, as the expression of ERS-related genes in UC and CD may be the cause or subsequent changes in intestinal inflammation. Here, we used a three-step summary data-based Mendelian randomization (SMR) approach integrating multi-omics data to identify putative causal effects of ERS...