期刊论文

英文

Materials Today Advances

2590-0498

2022

14

100245

10.1016/j.mtadv.2022.100245

Distinguished professor of Liaoning Province [XLYC2002008]; Dalian Science and Technology Leading Talents Project [2019RD15]; "1+X" program for Clinical Competency enhancement-Interdisciplinary Innovation Project, Second Hospital of Dalian Medical University; Natural Science Foundation of Hunan Province [2020JJ40 05]

本校为其他机构

Triple-negative breast cancer (TNBC) metastasis is the cause of nearly 90% of breast cancer treatment failures as the side effects of clinical drugs and insufficient efficacy of single-modality therapy. Shikonin (SHK) is a naphthoquinone natural product from the herbal medicine Lithospermum erythrorhizon., which is widely used for cancer therapy as one kind of Chinese medicine for its significant anti-tumor, anti-metastatic, and anti-inflammatory effects. However, passive targeting of SHK to tumor location in vivo and long-term high dose administration is likely to decrease heart rate and indu...