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Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer

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成果类型:
期刊论文
作者:
Zhou, Hao;Huang, Jiangbo;Wang, Fang
通讯作者:
Fang Wang
作者机构:
[Zhou, Hao; Huang, Jiangbo] Hunan Univ Chinese Med, Dept Urol, Affiliated Hosp 2, Changsha 410001, Hunan, Peoples R China.
[Wang, Fang] Changsha Social Work Coll, Dept Med, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Fang Wang] D
Department of Medicine, Changsha Social Work College, Changsha 410004, Hunan, PR China
语种:
英文
关键词:
Bioinformatics;Bladder cancer;Circ_644;MSI2;RUNX3;microRNA-143-3p
期刊:
Cellular Signalling
ISSN:
0898-6568
年:
2023
卷:
104
页码:
110590
基金类别:
None.
机构署名:
本校为第一机构
院系归属:
第二中医临床医学院
摘要:
BACKGROUND: Studies are ongoing to examine the versatile functions of circular RNAs (circRNAs) in human diseases. This research investigates the effects of hsa_circ_0000644 (circ_644) and its related molecules on the malignant behavior of bladder cancer (BCa) cells. METHODS: Abundant bioinformatics analyses were performed to screen the key circRNA and its related molecules in BCa. Tumor tissues and the para-tumorous tissues were collected from 58 patients with BCa. Expression of RUNX family transcription factor 3 (RUNX3), circ_644, microRNA-143-3p (miR-143-3p), and musashi RNA binding protein ...

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