Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Junping Zhu;Jiaming Wei;Ye Lin;Yuanyuan Tang;Zhaoli Su;...

通讯作者：

Liqing Li<&wdkj&>Bin Liu<&wdkj&>Xiong Cai

作者机构：

[Zhaoli Su; Junping Zhu; Ye Lin; Yuanyuan Tang; Jiaming Wei] Department of Rheumatology, First Hospital, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China

[Yuanyuan Tang] College of Biology, Hunan University, Changsha, Hunan, 410082, China

[Zhaoli Su] The Central Research Laboratory, Hunan Traditional Chinese Medical College, Zhuzhou, China

[Zhaoli Su] Guangxi Provincial Key Laboratory of Preventive and Therapeutic Research in Prevalent Diseases in West Guangxi, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China

[Liqing Li] The Central Research Laboratory, Hunan Traditional Chinese Medical College, Zhuzhou, China. liliqing87@qq.com

通讯机构：

[Liqing Li] T

[Bin Liu] C

[Xiong Cai] D

The Central Research Laboratory, Hunan Traditional Chinese Medical College, Zhuzhou, China<&wdkj&>Guangxi Provincial Key Laboratory of Preventive and Therapeutic Research in Prevalent Diseases in West Guangxi, Youjiang Medical University for Nationalities, Baise, China<&wdkj&>College of Biology, Hunan University, Changsha, China<&wdkj&>Department of Rheumatology, First Hospital, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Halofuginone hydrobromide;Rheumatoid arthritis;Network pharmacology;Molecular docking;Experimental validation

期刊：

BMC Complementary Medicine and Therapies

ISSN：

2662-7671

年：

2024

卷：

期：

页码：

1-12

DOI：

10.1186/s12906-024-04397-2

基金类别：

This study was funded by grants from the National Natural Science Foundation of China (82274506, 82104871), the China Postdoctoral Science Foundation (2022M721128), the Science and Technology Innovation Program of Hunan Province (2020SK1020, 2021RC4035), the Natural Science Foundation of Guangxi (2020GXNSFAA297053) and of Hunan (2023JJQNJJ2902), the Open-competing Disciple Construction Project of Hunan University of Chinese Medicine (HNUCM) (22JBZ003), and was financially supported by the Furong Distinguished Scholar Program of Hunan (XJT[2020]58), the “121” Training Project for Innovative Talents of Hunan (XRSH[2019]192), the Chinese Academy of Engineering Academician Liang Liu’s Workstation Project (KH[2023]3-23YS001), World First-class Discipline Incubation Project of HNUCM (XJF[2022]57) and Postgraduate Scientific Research Innovation Project of Hunan (CX20220795).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Rheumatoid arthritis (RA) is a prevalent autoimmune disease marked by chronic synovitis as well as cartilage and bone destruction. Halofuginone hydrobromide (HF), a bioactive compound derived from the Chinese herbal plant Dichroa febrifuga Lour., has demonstrated substantial anti-arthritic effects in RA. Nevertheless, the molecular mechanisms responsible for the anti-RA effects of HF remain unclear. METHODS: This study employed a combination of network pharmacology, molecular docking, and experimental validation to investigate poten...

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Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation

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