Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury

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成果类型：

期刊论文

作者：

Hu, En;Li, Teng;Li, Zhilin;Su, Hong;Yan, Qiuju;...

通讯作者：

Tang, Tao;Wang, Y

作者机构：

[Wang, Yang; Su, Hong; Yan, Qiuju; Hu, En; Tang, Tao; Li, Teng; Li, Zhilin] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

[Su, Hong; Yan, Qiuju; Hu, En; Tang, Tao; Li, Teng; Li, Zhilin] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.

[Wang, Lei] Xiangxiang Peoples Hosp, Dept Resp Dis, Xiangxiang, Peoples R China.

[Li, Haigang] Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha, Peoples R China.

[Zhang, Wei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

通讯机构：

[Tang, T; Wang, Y ] C

Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Network pharmacology;brain-derived neurotrophic factor;signal transducer and activator of transcription 3;growth-associated protein 43;cortex;hippocampus;traditional Chinese medicine

期刊：

Pharmaceutical Biology

ISSN：

1388-0209

年：

2023

卷：

期：

页码：

1054-1064

DOI：

10.1080/13880209.2023.2229379

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Context Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment. Objective To explore the therapeutic effects and underlying mechanisms of HSYA on post-TBI neurogenesis and axon regeneration. Materials and methods Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), and HSYA groups. Firstly, the modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's staining, and immunofluorescence of Tau1 and doublecortin (DCX) w...

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Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury

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