目的探讨筋骨片的镇痛抗炎作用。方法用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足跖肿胀模型,考察筋骨片的抗炎作用;用小鼠醋酸扭体法和热板法,观察筋骨片的镇痛作用。结果灌胃给予小鼠筋骨片药液4.42,8.84,17.68 g.kg-1后,对醋酸引起的小鼠扭体反应有明显的抑制作用,抑制率分别为30.9%,40.5%和50.6%;各剂量筋骨片药液在30120 m in均能明显提高小鼠热板痛阈值(P
摘要(英文):
Objective To study the analgesic and anti-inflammatory effects of jingu tablets (JGT) in animals, Methods A mouse model of ear swelling induced by xylene smearing and a rat model of hind paw swelling caused by hypodermic injection of carrageenan were used to study the anti-inflammatory effects of JGT while hot plate test and writhing reflex produced by intraperitoneal injection of acetic acid in mice were adopted for the examination of the analgesic effect of the drug. Results 4.42,8.84 and 17.68 g ·kg^-1 of JGT per mouse administered by gas...