期刊论文

Influence of Fuke Qianjin Tablets on ICAM-1 and MMP-2 in Acute Pelvic Inflammatory Models of Rats

中文

医药导报

1004-0781

2012

31

8

972-974

10.3870/yydb.2012.08.002

湖南省教育厅高校创新平台开放基金资助（10K045）；

本校为第一机构

目的 观察妇科千金片对急性盆腔炎模型大鼠子宫、卵巢、输卵管细胞间黏附分子1(ICAM-1)与基质金属蛋白酶2(MMP-2)表达的影响,探讨该药治疗盆腔炎的机制.方法 将80只雌性Wistar大鼠随机分为8组,除空白组和假手术组外,其他各组建立急性盆腔炎模型,给药21 d后取子宫、输卵管、卵巢,免疫组织化学法观察ICAM-1与MMP-2表达情况.结果 与空白组和假手术组比较,模型组大鼠子宫、卵巢、输卵管组织ICAM-1表达升高,MMP-2表达降低(P＜0.05)；与模型组比较,妇科千金片中、高剂量组和妇炎康组、罗红霉素组大鼠子宫、卵巢、输卵管组织ICAM-1表达下降,MMP-2表达升高(P＜0.05)；与罗红霉素组和妇炎康组比较,妇科千...

Objective To investigate the effects of fuke qianjin tablets on ICAM-1 and MMP-2 in acute pelvic inflammatory models of rats.Methods The rat models with acute pelvic inflammatory disease（Wistar female rats） were successfully established by injecting three kinds of bacteria（Escherichia coli,Ureaplasma urealyticum and Staphylococcus aureus） into the uterus.The rats were randomly divided into 8 groups and the ICAM-1 and MMP-2 positive cells in the pelvic tissues were tested by immunohistochemistry（SABC）,after 21 days of treatment.Results Com...