Objective To study the content of monoamine neurotransmitters and neurotrophic factor in the hippocampus,amygdala and prefrontal cortex in anxious depression rats,and explore the possible pathogenesis. Methods 60 SD rats were randomly divided into normal group,vehicle group,anxiety group,depression group,and anxious depression group,12 rats in each group. Chronic restraint stress combined with corticosterone injection was used to establish anxiety and depression model,the modeling time was 21 d. After modeling,elevated plus maze test,open field test,and forced swimming test were used to evalua...
