Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis

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成果类型：

期刊论文

作者：

Li, Yu-Lan;Gan, Xin-Li;Zhu, Rong-Ping;Wang, Xuehong;Liao, Duan-Fang;...

通讯作者：

Jin, Junfei;Huang, Zhaoquan

作者机构：

[Zhu, Rong-Ping; Jin, Junfei; Li, Yu-Lan; Gan, Xin-Li] Guilin Med Univ, Affiliated Hosp, Lab Hepatobiliary & Pancreat Surg, Guilin 541001, Guangxi, Peoples R China.

[Jin, Junfei; Li, Yu-Lan] Guilin Med Univ, Guangxi Key Lab Mol Med Liver Injury & Repair, Guilin 541001, Guangxi, Peoples R China.

[Jin, Junfei; Li, Yu-Lan] Guilin Med Univ, China USA Lipids Hlth & Dis Res Ctr, Guilin 541001, Guangxi, Peoples R China.

[Huang, Zhaoquan; Wang, Xuehong] Guilin Med Univ, Dept Pathol, Affiliated Hosp, 15 Lequn Rd, Guilin 541001, Guangxi, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

通讯机构：

[Jin, Junfei; Huang, Zhaoquan] G

Guilin Med Univ, Affiliated Hosp, Lab Hepatobiliary & Pancreat Surg, Guilin 541001, Guangxi, Peoples R China.

Guilin Med Univ, Dept Pathol, Affiliated Hosp, 15 Lequn Rd, Guilin 541001, Guangxi, Peoples R China.

语种：

英文

关键词：

Pt(II)-Bpy;anticancer activity;apoptosis;DNA damage;S-phase arrest;HepG2.

期刊：

Anti-Cancer Agents in Medicinal Chemistry

ISSN：

1871-5206

年：

2020

卷：

期：

页码：

504-517

DOI：

10.2174/1871520619666191112114340

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572738]; Natural Science Foundation of GuangxiNational Natural Science Foundation of Guangxi Province [2015GXNSFEA139003]; Lijiang Scholar Award in Guilin [2017004]; High Level of Innovation Team and Outstanding Scholars Program in Colleges and Universities in Guangxi [2017-38-08]; Hundred Talents Program "the Introduction of Overseas High-Level Talents in Colleges and Universities in Guangxi" [2014-8-13]; Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of ChinaMinistry of Education, China [CMEMR2015-B13]; Innovation Project of Guangxi Graduate Education [XYCBZ2019003]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Objective: To overcome the disadvantages of cisplatin, numerous platinum (Pt) complexes have been prepared. However, the anticancer activity and mechanism of Pt(II) complexed with 2-benzoylpyridine [Pt(II)Bpy]: [PtCl2(DMSO)L] (DMSO = dimethyl sulfoxide, L = 2-benzoylpyridine) in cancer cells remain unknown. Methods: Pt(II)-Bpy was synthesized and characterized by spectrum analysis. Its anticancer activity and underlying mechanisms were demonstrated at the cellular, molecular, and in vivo levels. Results: Pt(II)-Bpy inhibited tumor cell growth, ...

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Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis

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