期刊论文

Jin, JF;Huang, ZQ

英文

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY

1871-5206

2020

20

4

504-517

10.2174/1871520619666191112114340

This study was supported in part by the National Natural Science Foundation of China (No. 81572738), the Natural Science Foundation of Guangxi (No. 2015GXNSFEA139003), the Lijiang Scholar Award in Guilin (2017004), the High Level of Innovation Team and Outstanding Scholars Program in Colleges and Universities in Guangxi (2017-38-08), Hundred Talents Program “the Introduction of Overseas High-Level Talents in Colleges and Universities in Guangxi” (2014-8-13). This research was also supported by Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), Ministry of Education of China (No. CMEMR2015-B13). The project was also funded by the Innovation Project of Guangxi Graduate Education (No. XYCBZ2019003).

本校为其他机构

Objective: To overcome the disadvantages of cisplatin, numerous platinum (Pt) complexes have been prepared. However, the anticancer activity and mechanism of Pt(II) complexed with 2-benzoylpyridine [Pt(II)- Bpy]: [PtCl2(DMSO)L] (DMSO = dimethyl sulfoxide, L = 2-benzoylpyridine) in cancer cells remain unknown. Methods: Pt(II)-Bpy was synthesized and characterized by spectrum analysis. Its anticancer activity and underlying mechanisms were demonstrated at the cellular, molecular, and in vivo levels. Results: Pt(II)-Bpy inhibited tumor cell g...