期刊论文

Yang, S.

中文

湖南大学学报(自然科学版)

1674-2974

2007

34

8

48-53

国家自然科学基金资助项目（20472018）； 湖南省自然科学基金资助项目（03JJY3016）；

本校为其他机构

用二正丁基氧化锡和取代芳香单羧酸以1∶2摩尔比反应,合成了10个芳香型二正丁基锡双羧酸酯n-Bu_2Sn（OOCAr）_2（3a-3j）.利用~1H NMR,~(119)Sn NMR和IR等对这些化合物进行了表征.并用X-射线单晶衍射测定了其中化合物3b和3e的晶体结构.3b和3e晶体中锡原子配位数均为6,形成了严重扭的曲八面体几何构型.3b和3e均存在分子内及分子间氢键作用,3b中氢键作用较弱,在生物体系中比3e更易释放出游离态R_2Sn~(2＋),易与癌细胞的DNA结合,具有更好的抗癌生物活性。

A series of di-nbutyltin dicarboxylates nBu2Sn(OOCAr)2(3a-3j) were synthesized by the reaction of di-nbutyltin oxide with the corresponding aromatic carboxylic acids in 1:2 molar ratio. These compounds were characterized by 1HNMR, 119SnNMR and IR. Compounds 3b and 3e were determined by X-ray single crystal diffraction. In the crystals of 3b and 3e, each tin atom is six coordinated in a distorted octahedron geometry structure. The structures of 3b and 3e exist in their crystals by intermolecular and intramolecular hydrogen bonds. 3b presented better anticancer activity because the hydrogen bond...