期刊论文

Fabrication and Characterization of Novel PHBV/dextran Nanoparticles Drug Delivery System

Liu, Hairong(liuhairong@hnu.edu.cn)

中文

湖南大学学报(自然科学版)

1674-2974

2018

45

6

113-119

10.16339/j.cnki.hdxbzkb.2018.06.017

湖南省自然科学基金资助项目（2016JJ2023）； 湖南省科技计划项目（2015TP1035）； 湖南省研究生创新基地（2014-2017）； 湖南大学交叉学科研究项目（2014JCA09）~~；

本校为其他机构

两亲性聚合物纳米颗粒作为疏水性抗肿瘤药物载体因其能够增强化疗效率并降低毒副作用而受到广泛关注.采用双乳液溶剂挥发法制备了聚(3-羟基丁酸酯-co-3-羟基戊酸酯)(PHBV)/葡聚糖纳米颗粒,测得平均粒径为$205.0 \pm 6.9\;{\rm{nm}}$,Zeta电势为$ - 1.59 \pm 0.12\;{\rm{mV}}$,纳米颗粒具有明显的壳核结构,粒径均一,分散性良好.将疏水性化疗药物顺铂包载后,其粒径及电势均无明显变化,载药量达$19.3 \pm 2.9\% $.顺铂在模拟肿瘤细胞环境${\rm{pH}} = 5.5$的磷酸盐缓冲液(PBS)中比正常细胞环境${\rm{pH}} = 7.4$时释放更快,且累计释放周期均长达7d以上,表明该药物载体具有一定的pH响应性以及优异的...

Amphiphilic polymer nanoparticles have attracted considerable attention especially as anticancer drug delivery system, since they can enhance bioavailability and reduce side effects of drugs used for chemotherapy. Novel poly (3-hydroxybutyric-co-3-hydroxyvaleric, PHBV)/dextran nanoparticles (PDNPs) drug delivery system was formulated via an original double emulsion (w1/o1/w2) solvent-evaporation method. The mean diameter of PDNPs was 205.0±6.9 nm and their zeta potential was -1.59±0.12 mV by using dynamic light scattering (DLS) detection. PDNPs showed obvious core-shell structure...