期刊论文

中文

护理研究

1009-6493

2015

31

3872-3875

10.3969/j.issn.1009-6493.2015.31.009

湖南省科技计划项目,编号:2012FJ4354；

本校为第一机构

[目的]探讨象皮生肌膏治疗2型糖尿病大鼠溃疡，观察溃疡创面肉芽组织转化生长因子β(TGF β)及纤维结合蛋白(FN)表达的影响。[方法]从160只 SD 大鼠中随机挑选40只为空白对照组，其余120只 SD 大鼠制备2型糖尿病模型，成模后再制备溃疡模型，其中糖尿病模型大鼠按照血糖及体重分层随机分为模型组、阳性对照组及实验组，每组40只；模型组予生理盐水纱布外敷，阳性对照组予水胶体敷料外敷，实验组予象皮生肌膏外敷。分别在第1天、第7天、第14天、第21天从每组随机挑选10只处死并取相同部位创面组织制成切片，采用免疫组化法检测 TGF β及 FN 含量。[结果]除空白对照组 TGF β和 FN 无明显变化，其...

Objective:To take elephantiasis myogenic cream to treat type 2 diabetes of rat ulcer and observe the changes of transforming growth factor beta (TGF β)and fibronectin (FN)content in ulcer wound granula-tion tissue.Methods:Totally 40 rats were randomly selected as control group from 1 60 SD rats.The other 120 SD rats were made into type 2 diabetes models.After the ulcer model prepared,the ulcer rats models were made.These model rats were randomly divided into model group,positive control group and experimental group based on blood glucose and b...