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被撤回的出版物: Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP Induced Injury in HSCs (Retracted article. See vol. 13, 2022)

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成果类型:
期刊论文
作者:
Zhang, Wei;Zhu, Jia-huan;Xu, Hao;Huang, Xiao-Ping;Liu, Xiao-Dan;...
通讯作者:
Deng, CQ
作者机构:
[Xu, Hao; Zhu, Jia-huan; Zhang, Wei; Liu, Xiao-Dan] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha, Hunan, Peoples R China.
[Deng, Chang-Qing; Huang, Xiao-Ping] Hunan Univ Chinese Med, Key Lab Coll & Univ Hunan Prov Cytobiol & Mol Bio, Changsha, Hunan, Peoples R China.
通讯机构:
[Deng, CQ ] H
Hunan Univ Chinese Med, Key Lab Coll & Univ Hunan Prov Cytobiol & Mol Bio, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
Astragali radix (AR);Angelicae Sinensis Radix;hemopoiesis;Hematopoietic stem sell;cyclin
期刊:
Frontiers in Pharmacology
ISSN:
1663-9812
年:
2019
卷:
10
期:
JULY
页码:
463476
基金类别:
This work was supported by the grants from the National Nature Science Foundation of China (No.81473581, No.81774032, No.81874406), Hunan Natural Science Foundation (No.2016JJ4069), and Hunan Education Department open Foundation (No.15k089).
机构署名:
本校为第一且通讯机构
院系归属:
中西医结合学院
摘要:
Although the compatibility of Astragali Radix (AR) and Angelicae Sinensis Radix (ASR) has favorable effect on promoting hematopoiesis in traditional Chinese medicine (TCM), the main active components and pharmacological mechanism are unknown. We investigated the five active components and its mechanisms in vitro and in vivo. Five active components of Astragalus glycosides (AST), Formononetin (FRM), Ferulic acid (FRA), Calycosin (CAL), and Calycosin-7-glucoside (CLG), which could be absorbed in intestinal tract, were detected in this study. The peripheral blood, hematopoietic growth factors (HG...

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