A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease

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成果类型：

期刊论文

作者：

Tian, Feng-Ming;Yi, Jian;Tang, Yan;Chen, Bo-Wei;Long, Hong-Ping;...

通讯作者：

Bai-Yan Liu

作者机构：

[Liu, Ying-Fei; Yi, Jian; Ou-yang, Yin; Liu, Bai-Yan; Chen, Bo-Wei; Tang, Rong-Mei; Long, Hong-Ping; Tian, Feng-Ming] Hunan Univ Chinese Med, Affiliated Hosp 1, 95 Shaoshan Rd, Changsha, Peoples R China.

[Yi, Jian; Liu, Bai-Yan] Hunan Acad Chinese Med, 58 Lushan Rd, Changsha, Peoples R China.

[Liu, Ying-Fei; Yi, Jian; Ou-yang, Yin; Chen, Bo-Wei; Tang, Rong-Mei; Tian, Feng-Ming] Hunan Univ Chinese Med, 300 Xueshi Rd, Changsha, Peoples R China.

[Tang, Yan] Yiyang Med Coll, 516 Yingbin Rd, Yiyang, Peoples R China.

[Zhang, Wen-Jiang] Shaanxi Univ Chinese Med, Xixian Ave,Xixian New Area, Xianyang, Peoples R China.

通讯机构：

[Bai-Yan Liu] T

The First Affiliated Hospital, Hunan University of Chinese Medicine, 95 Shaoshan Road, Changsha, China<&wdkj&>Hunan Academy of Chinese Medicine, 58 Lushan Road, Changsha, China

语种：

英文

期刊：

Food & Function

ISSN：

2042-6496

年：

2023

卷：

期：

页码：

3686-3700

DOI：

10.1039/d2fo02774g

基金类别：

National Natural Science Foundation of China [82074251]; Excellent Youth Project of Science and Technology Department of Hunan Provincial Department of Education [19B575]; National Natural Science Foundation of Hunan Province [2022JJ30357]; Research Program of Hunan Provincial Health Commission [B202301028213]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

The possible mechanism by which the active components of Anhua fuzhuan tea act on FAM in NAFLD lesions was investigated. 83 components of Anhua fuzhuan tea were analysed by UPLC-Q-TOF/MS. Luteolin-7-rutinoside and other compounds were first discovered in fuzhuan tea. According to the TCMSP database and the Molinspiration website tool to predict and review the literature reports, 78 compounds were identified in fuzhuan tea with possible biological activities. The PharmMapper, Swiss target prediction, and SuperPred databases were used to predict the action targets of biologically active compound...

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A UPLC-Q-TOF/MS and network pharmacology method to explore the mechanism of Anhua fuzhuan tea intervention in nonalcoholic fatty liver disease

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