UPLC-Q-TOF-MS, Network Pharmacology and Molecular Docking to Reveal the Antidepressant Mechanism of the Different Components of Medicinal and Edible Lilies (Lilium sp. pl)

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tan, Zhaoyang;Huang, Linghe;Tian, Yanqiu;Jiang, Sai;Wang, Zhi;...

通讯作者：

Jiang, L

作者机构：

[Tong, Qiaozhen; Huang, Linghe; Wang, Zhi; Tian, Yanqiu; Jiang, Lin; Tan, Zhaoyang; Li, Shunxiang] Hunan Univ Chinese Med, Hunan Engn Technol Res Ctr Bioact Subst Discovery, Sch Pharm, Changsha 410208, Peoples R China.

[Long, Hongping] Hunan Univ Chinese Med, Hosp 1, Ctr Med Res & Innovat, Changsha 410007, Peoples R China.

[Jiang, Sai] Hunan Acad Chinese Med, Inst Innovat Tradit Chinese Medicat, Changsha 410013, Peoples R China.

[Huang, Linghe; Wang, Zhi; Tian, Yanqiu; Jiang, Lin; Tan, Zhaoyang; Li, Shunxiang] Hunan Univ Chinese Med, Hunan Prov Sino US Int Joint Res Ctr Therapeut Dru, Sch Pharm, Changsha 410208, Peoples R China.

[Jiang, Lin; Li, Shunxiang] Changsha Concord Herbs Cultivat Technol Co Ltd, Changsha 410221, Peoples R China.

通讯机构：

[Jiang, L ] H

Hunan Univ Chinese Med, Hunan Engn Technol Res Ctr Bioact Subst Discovery, Sch Pharm, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Lilium Brownii;Lilium Davidii;Lilium lancifolium;action mechanism.;component analysis;depression

期刊：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

ISSN：

1386-2073

年：

2025

卷：

页码：

1-22

DOI：

10.2174/0113862073368704250131085339

基金类别：

National Natural Science Foundation of China [82104055]; China Agriculture Research System of MOF and MARA [CARS-21]; Hunan Provincial Department of Education Science Research Project [22B0396]; Liu Liang Academician Workstation Guidance Project [24YS004]; Key Discipline of Biological Engineering in the Fourteenth Five-year Plan of Hunan University of Chinese Medicine (XiaoXingFaGuiZi-2023) [2]; Natural Science Foundation of Hunan [2021JJ80013, 2023JJ60473]; Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine (XiaoXingFaGuiZi-2023) [2]; China Postdoctoral Science Foundation [2020M671163]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

BACKGROUND AND OBJECTIVES: To explore the mechanism of action of the differential components of medicinal and edible lilies in treating depression by network pharmacology using UPLC-Q-TOF-MS technology. METHODS: The chemical composition of medicinal and edible lilies was analyzed, screening for unique medicinal compounds. Searched for depression-related targets. Constructed PPI networks. Performed GO and KEGG analyses. Built a network of differential components, and conducted molecular docking. In addition, the contents of regaloside before and...

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UPLC-Q-TOF-MS, Network Pharmacology and Molecular Docking to Reveal the Antidepressant Mechanism of the Different Components of Medicinal and Edible Lilies (Lilium sp. pl)

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