期刊论文

中文

中国畜牧兽医

1671-7236

2009

6

99-101

基金项目：湖南省科技厅基金（2060503）.

本校为第一机构

试验旨在测定MKR转基因2型糖尿病小鼠生物学特性数据,为2型糖尿病研究提供技术平台。由美国国立卫生研究院（NIH）授权使用引进的MKR鼠,经自然交配后繁殖的子代作为研究对象,测定MKR鼠的体重、血糖、记忆力、抗疲劳、耐缺氧、麻醉耐受试验,同期采用昆明小鼠和C57BL/6J小鼠作为对照。结果表明,新生MKR鼠自出生3周开始,血糖增高,体重随年龄的增加而减慢,与对照组小鼠同期比较,具有非常显著性意义,MKR鼠抗疲劳、耐缺氧、麻醉耐受能力比昆明小鼠差（P

To develop a diabetic mouse model to determine the data of biological property in MKR mice, a model in which expression of a dominant-negative IGF-I receptor in the skeletal muscle leads to systemic insulin resistance and diabetes, so as to provide a platform for researches about the type 2 diabetes. MKR mice were received from the National Institutes of Health, USA, and propagated naturally. These mice were followed up for body weight, blood glucose level, faculty of memory, fatigue- resistant ,oxygen-deficiency-enduring and experiment of anae...