Diabetes mellitus with depression is secondary to diabetes and is one of the chronic complications with the highest suicide rate. The pathogenesis of diabetes mellitus with depression mainly focuses on the hypothalamus-pituitary-adrenal axis（HPA axis） dysfunction and hippocampal damage. The two mechanisms worsen each other. In addition to conventional medical treatment, psychological intervention and exercise therapy help improve the hyperglycemic condition and symptoms of anxiety and depression in patients of diabetes mellitus with depression, a...
