期刊论文

Matrix prescription of Xiao＇er Jianpi Wentong plaster

中文

中南药学

1672-2981

2016

14

12

1324-1327

10.7539/j.issn.1672-2981.2016.12.010

No.2013SK2026:湖南省科技计划重点项目 No.k1307164-31:长沙市科技计划重点项目

本校为第一机构

目的优化小儿健脾温通贴的基质处方。方法采用单因素方差分析结合星点设计-效应面优化法,以剥离强度为量化指标,结合膏体的皮肤追随性、赋型性、外观等指标的加权综合评分,优选出最佳基质处方。结果小儿健脾温通贴的最优处方为明胶-聚乙烯吡咯烷酮K30（PVPK30）-聚丙烯酸钠-甘油=4.0∶2.08∶5.16∶24。结论以最优基质处方制备的凝胶贴膏剂,具有良好的黏附性和外观,成形性好。

Objective To optimize the matrix prescription of Xiao＇er Jianpi Wentong plaster. Methods We Used single factor experiment with central composite design-response surface method, and took peeling strength as the quantitative index, together with adhesive ability, formability, appearance as indexes, to optimize matrix prescription. Results The optimal ratio of the matrix was as follows： gelatin-PVPK30-sodium polyacrylateglycerin（4.0∶2.08∶5.16∶24）. Conclusion The optimal matrix has good adhesion, appearance, an...