期刊论文

Effect of Yixintai effective component on cardiac function and ultrastructure in rabbits with heart failure after myocardial infarction

中文

中南药学

1672-2981

2020

18

3

379-383

10.7539/j.issn.1672-2981.2020.03.008

国家自然科学基金项目（编号:81673955）； 湖南省自然科学基金项目（编号:2017JJ2206）； 湖南中医药大学一流学科开放基金项目（编号:2018ZYX43）；

本校为第一机构

目的 观察益心泰有效组分对心肌梗死后心力衰竭兔的心功能及心肌超微结构的影响.方法 参照文献采用结扎左冠状动脉前降支法+ PTU灌胃复制心肌梗死后心力衰竭兔模型,造模成功后,随机分为模型组,益心泰低、中、高剂量组及氯沙坦钾组.各组予以相应药物,连续灌胃4周后行心脏彩色多普勒超声检查,并采集心肌样本,行HE染色及透射电镜.结果 与模型组相比,益心泰中、高剂量组与氯沙坦钾组心脏收缩功能指标(LVEF、LVFS)和舒张功能指标(E/A比值)升高(P＜0.05),心脏结构性指标(LVIDs、LVIDd)降低(P＜0.05),益心泰高剂量组与氯沙坦钾组心脏指数、左心室重量指数降低(P＜0.05).治疗效果上,益心泰高剂量组及氯沙...

Objective To observe the effect of Yixintai effective components on cardiac function and ultrastructure in rabbits with chronic heart failure after myocardial infarction. Methods Reference literature was used to help establish rabbit models of heart failure after myocardial infarction by ligation of the left anterior descending coronary artery + PTU. After the successful modeling, they were randomly divided into a model group, Yixintai low-, medium-and high-dose groups and a losartan potassium group. Each group was given the corresponding drug. After continuous gavage for 4 weeks, cardiac colo...