期刊论文

中文

中国中医药信息杂志

1005-5304

2005

12

5

29-30

10.3969/j.issn.1005-5304.2005.05.013

湖南省教育厅科研基金立项（03C297）； 湖南中医学院中医诊断学国家重点学科资助项目；

本校为第一机构

目的观察桃仁-红花"药对"不同配比的血府逐瘀汤抗垂体后叶素(Pit)致大鼠急性心肌缺血的作用.方法采用大鼠舌下静脉注射Pit造成急性心肌缺血模型,观察各给药组注射Pit后不同时间点Ⅱ导联心电图ST段变化以及血清乳酸脱氢酶(LDH)、肌酸激酶(CK)、超氧化物歧化酶(SOD)、丙二醛(MDA)的含量.结果桃仁、红花不同配比的血府逐瘀汤对Pit所致缺血性ST段有明显改善作用,能明显增加血清SOD的活性,降低MDA、CK和LDH的含量,其中桃仁、红花配比为4:3时效果最为显著.结论桃仁、红花不同配比的血府逐瘀汤均具有明显对抗Pit致大鼠急性心肌缺血的作用,其功效与桃仁-红花的不同配比之间关系不明显.

Objective To observe the effects of Xiefuzhuyu Decoction of different compatible proportion of peach kernel and safflower on the rats model of acute myocardial ischemia by pituitrin injection. Methods Pituitrin was injected into dorsal veins of tongue to reproduce the model of acute myocardium ischemia. The changes of the ST segment of Ⅱ road electrocardiogram and contents of LDH, CK, SOD, MDA in serum were observed after pituitrin injection. Results Xiefuzhuyu Decoction of different compatible proportion of peach kernel and safflower could si...