The anti-dementia drug candidate, (−)-clausenamide, improves memory impairment through its multi-target effect

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chu, Shifeng;Liu, Shaolin;Duan, Wenzhen;Cheng, Yong;Jiang, Xueying;...

通讯作者：

Zhang, Juntian

作者机构：

[Yu, Xiaoming; Cheng, Yong; Wu, Kemei; Wang, Yan; Wang, Muzou; Zhang, Juntian; Zhu, Chuanjiang; Chu, Shifeng] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.

[Yu, Xiaoming; Cheng, Yong; Wu, Kemei; Wang, Yan; Wang, Muzou; Zhang, Juntian; Zhu, Chuanjiang; Chu, Shifeng] Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

[Huang, Huiyong; Chu, Shifeng] Hunan Univ Chinese Med, Collaborat Innovat Ctr Digital Tradit Chinese Med, Key Lab Diagnost Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Liu, Shaolin] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA.

[Liu, Shaolin] Univ Maryland, Sch Med, Program Neurosci, Baltimore, MD 21201 USA.

通讯机构：

[Zhang, Juntian] P

[Zhang, Juntian] C

Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Chirality;Clausenamide;Dementia;Long-term potentiation;Signaling pathway;Calcium

期刊：

Pharmacology & Therapeutics

ISSN：

0163-7258

年：

2016

卷：

162

页码：

179-187

DOI：

10.1016/j.pharmthera.2016.01.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [3080152730973887, U0832008]; National Key Major Item [2008ZX09101-015]

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Multi-target drugs, such as the cocktail therapy used for treating AIDS, often show stronger efficacy than single target drugs in treating complicated diseases. This review will focus on clausenamide (clau), a small molecule compound originally isolated from the traditional Chinese herbal medicine, Clausenalansium. The finding of four chiral centers in clau molecules predicted the presence of 16 clau enantiomers, including (-)-dau and (+)-clau. All of the predicted enantiomers have been successfully synthesized via innovative chemical approaches, and pharmacological studies have demonstrated (...

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The anti-dementia drug candidate, (−)-clausenamide, improves memory impairment through its multi-target effect

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