Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Jiye;Chen, Jiayao;Li, Qinxia;Hu, Minxia;Zhong, Xingxing;...

通讯作者：

Xiong, W

作者机构：

[Liu, Jing; Chen, Jiye] Yiyang Cent Hosp Hunan Prov, Burn & Plast Surg Dept, Yiyang 413000, Peoples R China.

[Zhong, Xingxing; Li, Qinxia; Yu, Liang; Huang, Hongyu; Hu, Minxia; Chen, Jiayao] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410003, Peoples R China.

[Zhang, Xi] Hunan Univ Chinese Med, Hunan Brain Hosp, Clin Med Sch, Changsha 410007, Peoples R China.

[Huang, Ziyi] Hunan Univ Chinese Med, Coll Acupuncture Massage & Rehabil, Changsha 410208, Peoples R China.

[Liu, Xinyi] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha 410003, Peoples R China.

通讯机构：

[Xiong, W ] H

Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Breast Surg, Changsha 410003, Peoples R China.

语种：

英文

关键词：

Diabetes;Astragaloside IV;MSC;Exosome;MiR-146a-5p;TRAF6;Inflammation

期刊：

In Vitro Cellular & Developmental Biology - Animal

ISSN：

1071-2690

年：

2025

卷：

期：

页码：

93-106

DOI：

10.1007/s11626-024-00984-2

基金类别：

This study was supported by the Clinical Medical Technology Innovation Guidance Project of Hunan Provincial Science and Technology Department (No.2021SK51412), the Clinical Medical Technology Innovation Guidance Project of Hunan Provincial Science and Technology Department (No. 2021SK50802), Science and Health Joint Project of Hunan Natural Science Foundation (No.2021JJ70033), Scientific Research Project of Hunan Provincial Health Commission (No.202204034510), and The National Natural Science Foundation of China (No. 82374276).

机构署名：

本校为通讯机构

院系归属：

中医学院

第一中医临床学院

中西医结合学院

针灸推拿与康复学院

摘要：

This study aimed to explore the potential of using mesenchymal stem cell (MSC)-derived exosomes (MSC-Exos) pre-treated with Astragaloside IV (ASIV) to alleviate inflammation in high glucose (HG)-damaged endothelial cells. MSC-Exos were isolated from untreated MSCs and ASIV-pre-treated MSCs, and their characteristics were assessed. The expression of miR-146a-5p in MSC-Exos was determined, and it was found that ASIV treatment enhanced its expression. In order to assess the impact of highly miR-146a-5p-expressing MSC-Exos on HG-injured endothelial...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问