Acacetin protects against depression-associated dry eye disease by regulating ubiquitination of NLRP3 through gp78 signal

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成果类型：

期刊论文

作者：

Xie, Mingxia;Wang, Hanqing;Peng, Jun;Qing, Dongqin;Zhang, Xi;...

作者机构：

[Meng, Pan; Luo, Zhihong; Peng, Qinghua; Xie, Mingxia; Guo, Dongwei; Zhang, Xi; Wang, Xiaoye] Hunan Univ Chinese Med, Coll Clin Med, Changsha, Hunan, Peoples R China.

[Meng, Pan; Peng, Qinghua; Xie, Mingxia] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Qing, Dongqin; Wang, Hanqing] Hunan Univ Chinese Med, Coll Pharm, Changsha, Hunan, Peoples R China.

[Peng, Jun; Peng, Qinghua] First Hosp Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Dry eye disease;Depression;NLRP3 ubiquitination;gp78;Acacetin

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2022

卷：

页码：

4244

DOI：

10.3389/fphar.2022.984475

基金类别：

China Postdoctoral Science Foundation [2021M690990]; "Academician Liu Liang Workstation" guidance project [21YS002]; "Disciplinary Reveal System" project [22JBZ024]; Scientific Research Project of Hunan Administration of traditional Chinese Medicine [D2022053]; Scientific Research Project of Hunan Provincial Health Commission [202107021634]; Hunan Provincial Department of Science and Technology, Hunan Clinical Medical Research Center [2021SK4022]; Key Projects of Hunan Provincial Department of Education [21A0238]

机构署名：

本校为第一机构

院系归属：

中医学院

药学院

摘要：

Dry eye disease (DED) is a multifactorial syndrome that commonly occurs with depression. However, therapies targeting depression-related dry eye disease are rare. In the current study, we studied the beneficial effect of a natural flavone, acacetin, in depression-associated dry eye disease by utilizing the chronic unpredictable mild stress (CUMS) depression model. Our data showed that acacetin improved the depressive behaviors in sucrose preference test (SPT), tail suspension test (TST) and forced swim test (FST); relieved the dry eye symptoms including corneal epithelial impairments, tear pro...

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Acacetin protects against depression-associated dry eye disease by regulating ubiquitination of NLRP3 through gp78 signal

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