期刊论文

Effect of Xuefu Zhuyu Decoction on PDGF Density in Serum in Atherosclerosis Rabbits

中文

湖南中医药大学学报

1674-070X

2006

26

3

15-17

10.3969/j.issn.1674-070X.2006.03.006

湖南省教育厅青年科研基金项目（No.0513034）； 湖南省中医药管理局科研基金项目（No.2004009）。；

本校为第一机构

目的 探讨活血化疼代表方血府逐瘀汤时动脉粥样硬化（AS）家兔血清血小板衍化生长因子（PDGF）的影响。方法 21只家兔随机分为空白组、模型组、血府逐瘀汤组。采用高脂喂饲复制家兔AS模型。以血府逐瘀汤对谊模型进行干预。观察各组家兔血清PDGF浓度、主动脉组织形态学的变化。结果 模型组家兔血清PDGF浓度明显高于空白组（P〈0．01）。家兔主动脉粥样硬化改变明显；血府逐瘀汤组家兔血清PDGF浓度明显低于模型组（P〈0．01）。主动脉粥样硬化病理改变优于模型组。结论 血府逐瘀汤具有抑制高脂喂饲致家兔AS病理改变的形成。其机制可能与降低血清PDGF浓度有关。

Objective To observe the effect of Xuefu zhuyu decoction on Platelet-derived growth factor （PDGF） density in serum in experimental atherosclerosis rabbits. Methods The Japan white rabbits were divided into control, hypercholesterol and Xuefu zhuyu decoction group, and fed high cholesterol diet. PDGF in serum was detected by ELISA and the histopathological changes of aorta were detected at 10 weeks. Results Compared with hypercholesterol group, Xuefu zhuyu decoction could reduce the PDGF density remarkably （P〈0.01）. The degree of atherioscl...