Hybridization chain reaction triggered poly adenine to absorb silver nanoparticles for label-free electrochemical detection of Alzheimer\'s disease biomarkers amyloid β-peptide oligomers - 成果

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Hybridization chain reaction triggered poly adenine to absorb silver nanoparticles for label-free electrochemical detection of Alzheimer's disease biomarkers amyloid β-peptide oligomers

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成果类型：

期刊论文

作者：

Liao, Xianjiu;Ge, Kezhen;Cai, Zhiheng;Qiu, Shang;Wu, Shengyue;...

通讯作者：

Tang, Qianli;Gao, Fenglei

作者机构：

[Tang, Qianli; Liao, Xianjiu] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Li, Qingli; Tang, Qianli; Liao, Xianjiu] Youjiang Med Univ Nationalities, West Guangxi Key Lab Prevent & Treatment High Inc, Baise 533000, Guangxi, Peoples R China.

[Liu, Zhao; Qiu, Shang; Wu, Shengyue; Gao, Fenglei; Cai, Zhiheng; Ge, Kezhen] Xuzhou Med Univ, Sch Pharm, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China.

通讯机构：

[Tang, Qianli] H

[Gao, Fenglei] X

Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

Xuzhou Med Univ, Sch Pharm, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China.

语种：

英文

关键词：

Aβ oligomers;DNA;Electrochemical;Label free;Silver nanoparticles

期刊：

Analytica Chimica Acta

ISSN：

0003-2670

年：

2022

卷：

1192

页码：

339391

DOI：

10.1016/j.aca.2021.339391

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21964018, 81860851]; Natural Science Foundation of Guangxi ProvinceNational Natural Science Foundation of Guangxi Province [2018 GXNSFAA138211, 2018GXNSFDA281017]; Distinguished Young Talents of Youjiang Medical University for Nationalities; Key Laboratory of Bioanalytical Chemistry and Clinical Molecular Diagnosis of Youjiang Medical University for Nationalities; Subject academic team of Youjiang Medical University for Nationalities (Pharmaceutical analysis); Application of Bioanalytical Chemistry and Development of Clinical Molecular Diagnosis of Baise Engineering Technology Research Center

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

摘要：

Amyloid beta-peptide oligomer (A beta O) has received extensive attention from researchers because of its clinical therapeutic intervention targets and the value of reliable biological macromolecules markers for early diagnosis of Alzheimer's disease. We have developed a novel label-free electrochemical detection sensor for A beta O based on hybridization chain reaction (HCR)-triggered poly adenine to absorb silver nanoparticles (AgNPs). In this method, we first use the "capture probe" to immobilize the aptamer 1 on the surface of the gold electrode (GE) via poly adenine-Au. Next, aptamer 2 an...

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Hybridization chain reaction triggered poly adenine to absorb silver nanoparticles for label-free electrochemical detection of Alzheimer's disease biomarkers amyloid β-peptide oligomers

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