Objective To optimize the extraction technology of Lianqin Jiedu granules. Methods The transfer rate of berberine hydrochloride and baicalin rate as indexes, combined with single factor and orthogonal test method, the extraction process of Qinlian Jiedu granule was optimized. Results The optimal extraction process was 60P ethanol immersion 1.0 h, re-flux extraction 2 times, the first time 1.5 h, 1:10 (gmL),second time 1 h, 1:8 (g:mL). Conclusion The optimized extraction technology is stable and feasible, provide experime...