Identification of Sialyl-Lewis(x)-Interacting Protein on Human Spermatozoa

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成果类型：

期刊论文

作者：

Wang, Ying;Zhao, Weie;Mei, Si;Chen, Panyu;Leung, Tsz-Ying;...

作者机构：

[Yeung, William S. B.; Chiu, Philip C. N.; Wang, Ying; Ou, Jian-Ping; Leung, Tsz-Ying; Lee, Cheuk-Lun; Mei, Si; Zhao, Weie] Univ Hong Kong, Dept Obstet & Gynecol, Queen Mary Hosp, Hong Kong, Peoples R China.

[Wang, Ying] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China.

[Chen, Panyu; Liang, Xiaoyan; Zhao, Weie] Sun Yat Sen Univ, Affiliated Hosp 6, Guangzhou, Peoples R China.

[Mei, Si] Hunan Univ Chinese Med, Dept Physiol, Med Coll, Changsha, Peoples R China.

[Yeung, William S. B.; Chiu, Philip C. N.; Leung, Tsz-Ying; Lee, Cheuk-Lun] Univ Hong Kong, Dept Obstet & Gynecol, Shenzhen Key Lab Feral Regulat, Shenzhen Hosp, Shenzhen, Peoples R China.

语种：

英文

关键词：

zona pellucida;human spermatozoa;sialyl-Lewis(x);C1orf56;fertilization rate

期刊：

Frontiers in Cell and Developmental Biology

ISSN：

2296-634X

年：

2021

卷：

DOI：

10.3389/fcell.2021.700396

基金类别：

Hong Kong Research Grant Council GrantHong Kong Research Grants Council [17116417]; Hong Kong Health and Medical Research Fund [07182446]; Sanming Project of Medicine in Shenzhen [81801447]; High Level-Hospital Program, Health Commission of Guangdong Province, China [HKUSZH201902041]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Capacitated spermatozoa initiate fertilization by binding to the zona pellucida (ZP). Defective spermatozoa-ZP binding causes infertility. The sialyl-Lewis(x) (SLeX) sequence is the most abundant terminal sequence on the glycans of human ZP glycoproteins involving in spermatozoa-ZP binding. This study aimed to identify and characterize the SLeX-binding proteins on human spermatozoa. By using affinity chromatography followed by mass spectrometric analysis, chromosome 1 open reading frame 56 (C1orf56) was identified to be a SLeX-binding protein of capacitated spermatozoa. The acrosomal region of...

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Identification of Sialyl-Lewis(x)-Interacting Protein on Human Spermatozoa

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