ANGPTL3: a novel biomarker and promising therapeutic target.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jiang, Shuang;Qiu, Guo-Hui;Zhu, Neng;Hu, Zhe-Yu;Liao, Duan-Fang;...

通讯作者：

Qin, Li

作者机构：

[Jiang, Shuang; Qiu, Guo-Hui; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Jiang, Shuang; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Qiu, Guo-Hui] Hunan Prov Peoples Hosp, Dept Pharm, Changsha, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

[Hu, Zhe-Yu] Cent S Univ, Hunan Canc Hosp, Xiangya Med Sch, Changsha, Hunan, Peoples R China.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

ANGPTL3;biological feature;biomarkers;therapeutic target;signalling pathway

期刊：

Journal of Drug Targeting

ISSN：

1061-186X

年：

2019

卷：

期：

页码：

876-884

DOI：

10.1080/1061186X.2019.1566342

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270359, 81774130, 81670268]; Key projects of Hunan traditional Chinese Medicine Administration [201614]; Science Foundation for Distinguished Young Scholars of Hunan ProvinceNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [2018JJ1018]; Hunan Provincial Key Discipline of Pharmaceutical Science

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

摘要：

Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein that mainly expresses in the liver, and is regulated by numerous post-translational modifications, including multiple cleavage and glycosylation. Accumulating evidences have revealed that ANGPTL3 plays a critical role in both biological processes, such as lipid metabolism, angiogenesis and haematopoietic function and pathological changes, including atherosclerosis, carcinogenesis, nephrotic syndrome, diabetes, liver diseases and so on. Thus, ANGPTL3 may serve as a potential biomarker in these diseases. Furtherm...

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ANGPTL3: a novel biomarker and promising therapeutic target.

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