期刊论文

中文

时珍国医国药

1008-0805

2018

29

1

1-3

10.3969/j.issn.1008-0805.2018.01.001

国家自然科学基金（81473617） 湖南省自然科学基金（2016JJ6113） 湖南省教育厅高校科研一般项目（15C1033） 中医内科学省部共建教育部重点实验室开放基金（ZYNK201504）

本校为第一机构

目的研究蜈蚣多肽对正常裸鼠和皮下移植性H22荷瘤裸鼠肝毒性的差异。方法分别对正常裸鼠和皮下H22荷瘤裸鼠予以蜈蚣多肽灌胃给药14 d,观察裸鼠的一般情况、肿瘤生长情况、肝毒性。结果低剂量蜈蚣多肽对荷瘤裸鼠的抑瘤率为32.74%。低剂量蜈蚣多肽使正常裸鼠ALT增高,高剂量蜈蚣多肽使正常裸鼠AST增高。低剂量蜈蚣多肽作用下,荷瘤裸鼠的ALT较正常裸鼠低,差异有统计学意义。蜈蚣多肽高剂量作用下,荷瘤裸鼠的AST、AST较正常裸鼠高,差异有统计学意义。结论低剂量蜈蚣多肽有一定抗肝细胞癌作用。相同剂量蜈蚣多肽对荷瘤裸鼠与正常裸鼠的肝损伤存在差异,蜈蚣肝毒性与抗肿瘤活性可能具有相关性。

Objective To study the effects of centipede polypeptide on H22 tumor - bearing mouse and normal mouse. Method- s Normal and tumor -bearing mouse were orally administrated by centipede polypeptide. Results of restraining tumor, hepatotox- icity were calculated after 14 days treatment. The restraining tumor rates of centipede polypeptide at low doses were 32.74%. Centipede polypeptide at low dose can increase ALT in normal nude mice, high dose can increase AST. Contrast with the normal mouse, the hepatotoxicity of centipede polypeptide at low dose were smaller, high dose were higher. Conclusion ...