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Systematic biological and proteomics strategies to explore the regulation mechanism of Shoutai Wan on recurrent spontaneous Abortion's biological network

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成果类型:
期刊论文
作者:
Zeng, Liuting*;Yang, Kailin*;Liu, Liting;Zhang, Tianqing;Liu, Huiping*;...
通讯作者:
Zeng, Liuting;Yang, Kailin;Liu, Huiping;Lei, Lei
作者机构:
[Zeng, Liuting] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China.
[Zeng, Liuting] Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing, Peoples R China.
[Yang, Kailin] Capital Med Univ, Beijing, Peoples R China.
[Yang, Kailin] Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China.
[Liu, Liting] Huazhong Univ Sci & Technol, Wuhan, Hubei, Peoples R China.
通讯机构:
[Zeng, Liuting; Yang, Kailin] C
[Liu, HP; Lei, L] H
Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China.
Capital Med Univ, Beijing, Peoples R China.
Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
Shoutai Wan;Recurrent spontaneous abortion;Two-dimensional separation;Systematic biology;Proteomics;Mass spectrometry
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2020
卷:
263
页码:
113156-
机构署名:
本校为通讯机构
摘要:
ETHNOPHARMACOLOGICAL RELEVANCE: Shoutai Wan (STW) is a classic herbal formula for the treatment of recurrent spontaneous abortion (RSA), and clinical studies have shown the effectiveness of STW on RSA. However, the molecular mechanism of STW treatment of RSA is still unclear. METHODS: (1) Animal experiments: The normal pregnancy model was established with CBA/J*BALB/C, and the RSA model was established by CBA/J*DBA/2. The RSA model CBA/J*DBA/2 pregnant mice were randomly divided into four groups (RSA model group, STW low, medium and high dose g...

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