Nardochinoid B Inhibited the Activation of RAW264.7 Macrophages Stimulated by Lipopolysaccharide through Activating the Nrf2/HO-1 Pathway

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成果类型：

期刊论文

作者：

Yao, Yun-Da;Shen, Xiu-Yu;Machado, Jorge;Luo, Jin-Fang;Dai, Yi;...

通讯作者：

Zhou, Hua;Liu, Zhong-Qiu

作者机构：

[Luo, Pei; Xie, Ying; Lio, Chon-Kit; Luo, Jin-Fang; Yao, Yun-Da; Zhou, Hua] Macau Univ Sci & Technol, Fac Chinese Med, Taipa 999078, Macao, Peoples R China.

[Luo, Pei; Xie, Ying; Lio, Chon-Kit; Luo, Jin-Fang; Yao, Yun-Da; Zhou, Hua] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China.

[Yao, Xin-Sheng; Shen, Xiu-Yu] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China.

[Machado, Jorge] Univ Porto, Abel Salazar Inst Biomed Sci, ICBAS, Lab Appl Physiol, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.

[Yao, Xin-Sheng; Yu, Yang; Dai, Yi] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China.

通讯机构：

[Zhou, Hua] M

[Liu, ZQ; Zhou, H] G

Macau Univ Sci & Technol, Fac Chinese Med, Taipa 999078, Macao, Peoples R China.

Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China.

Guangzhou Univ Chinese Med, Joint Lab Translat Canc Res Chinese Med, Minist Educ Peoples Republ China, Guangzhou 510006, Guangdong, Peoples R China.

语种：

英文

关键词：

Nardostachys chinensis;nardochinoid B;nitric oxide;inducible nitric oxide synthase;heme oxygenase-1

期刊：

Molecules

ISSN：

1420-3049

年：

2019

卷：

期：

DOI：

10.3390/molecules24132482

基金类别：

Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao of the National Natural Science Fund of China [81628016]; Macao Science and Technology Development Fund [062/2017/A2, 0027/2017/AMJ]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Nardochinoid B (NAB) is a new compound isolated from Nardostachys chinensis. Although our previous study reported that the NAB suppressed the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW264.7 cells, the specific mechanisms of anti-inflammatory action of NAB remains unknown. Thus, we examined the effects of NAB against LPS-induced inflammation. In this study, we found that NAB suppressed the LPS-induced inflammatory responses by restraining the expression of inducible nitric oxide synthase (iNOS) proteins and mRNA in...

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Nardochinoid B Inhibited the Activation of RAW264.7 Macrophages Stimulated by Lipopolysaccharide through Activating the Nrf2/HO-1 Pathway

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