Nardochinoid B inhibited the activation of RAW264.7 macrophages stimulated by lipopolysaccharide through activating the Nrf2/HO-1 pathway

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成果类型：

期刊论文

作者：

Yao, Yun-Da;Shen, Xiu-Yu;Machado, Jorge;Luo, Jin-Fang;Dai, Yi;...

通讯作者：

Zhou, H;Liu, Zhong-Qiu

作者机构：

[Zhou, H; Luo, Pei; Xie, Ying; Lio, Chon-Kit; Luo, Jin-Fang; Yao, Yun-Da; Zhou, Hua] Macau Univ Sci & Technol, Fac Chinese Med, Taipa 999078, Macao, Peoples R China.

[Zhou, H; Luo, Pei; Xie, Ying; Lio, Chon-Kit; Luo, Jin-Fang; Yao, Yun-Da; Zhou, Hua] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China.

[Yao, Xin-Sheng; Shen, Xiu-Yu] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China.

[Machado, Jorge] Univ Porto, Abel Salazar Inst Biomed Sci, ICBAS, Lab Appl Physiol, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.

[Yao, Xin-Sheng; Yu, Yang; Dai, Yi] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China.

通讯机构：

[Zhou, H ] M

[Liu, ZQ] G

Macau Univ Sci & Technol, Fac Chinese Med, Taipa 999078, Macao, Peoples R China.

Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China.

Guangzhou Univ Chinese Med, Joint Lab Translat Canc Res Chinese Med, Minist Educ Peoples Republ China, Guangzhou 510006, Guangdong, Peoples R China.

语种：

英文

关键词：

antiinflammatory agent;autacoid;cyclooxygenase 2;cytokine;heme oxygenase 1;immunoglobulin enhancer binding protein;inducible nitric oxide synthase;plant extract;transcription factor Nrf2;angiosperm;animal;biological model;biosynthesis;chemical structure;chemistry;drug effect;immunology;macrophage;macrophage activation;metabolism;mouse;physiology;RAW 264.7 cell line;signal transduction;Animals;Anti-Inflammatory Agents;Cyclooxygenase 2;Cytokines;Heme Oxygenase-1;Inflammation Mediators;Macrophage Activation;Macrophages;Magnoliopsida;Mice;Models, Biological;Molecular Structure;NF-E2-Related Factor 2;NF-kappa B;Nitric Oxide Synthase Type II;Plant Extracts;RAW 264.7 Cells;Signal Transduction

期刊：

Molecules

ISSN：

1420-3049

年：

2019

卷：

期：

页码：

2482

DOI：

10.3390/molecules24132482

基金类别：

This research was supported by the Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao of the National Natural Science Fund of China (Project No.: 81628016) and the Macao Science and Technology Development Fund (Project No: 062/2017/A2, 0027/2017/AMJ). Funding: This research was supported by the Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao of the National Natural Science Fund of China (Project No.: 81628016) and the Macao Science and Technology Development Fund (Project No: 062/2017/A2, 0027/2017/AMJ).

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Nardochinoid B (NAB) is a new compound isolated from Nardostachys chinensis. Although our previous study reported that the NAB suppressed the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW264.7 cells, the specific mechanisms of anti-inflammatory action of NAB remains unknown. Thus, we examined the effects of NAB against LPS-induced inflammation. In this study, we found that NAB suppressed the LPS-induced inflammatory responses by restraining the expression of inducible nitric oxide synthase (iNOS) proteins and mRNA in...

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Nardochinoid B inhibited the activation of RAW264.7 macrophages stimulated by lipopolysaccharide through activating the Nrf2/HO-1 pathway

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