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Exploring the Molecular Mechanism of Action of Yinchen Wuling Powder for the Treatment of Hyperlipidemia, Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

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成果类型:
期刊论文
作者:
Ye, Jiahao;Li, Lin;Hu, Zhixi*
通讯作者:
Hu, Zhixi
作者机构:
[Ye, Jiahao] Hunan Univ Chinese Med, Domest First Class Discipline Construct Project C, Changsha 410208, Hunan, Peoples R China.
[Li, Lin] Hunan Univ Chinese Med, Inst Tradit Chinese Med Diagnost, Changsha 410208, Hunan, Peoples R China.
[Hu, Zhixi] Hunan Univ Chinese Med, Postgrad Sch, Changsha, Hunan, Peoples R China.
通讯机构:
[Hu, Zhixi] H
Hunan Univ Chinese Med, Postgrad Sch, Changsha, Hunan, Peoples R China.
语种:
英文
期刊:
BioMed Research International
ISSN:
2314-6133
年:
2021
卷:
2021
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81774208]
机构署名:
本校为第一且通讯机构
院系归属:
研究生院
摘要:
Background. Yinchen Wuling powder is often used to treat clinical hyperlipidemia, although its mechanism of action remains unclear. In this study, we aimed to investigate the active ingredients found in Yinchen Wuling powder and find its mechanism of action when treating hyperlipidemia, using a combination of network pharmacology, molecular docking, and molecular dynamics simulation approaches. Methods. The TCMSP database was used to obtain the principle active ingredients found in Yinchen Wuling powder and the NCBI and DisGeNet databases were ...

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