Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

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成果类型：

期刊论文

作者：

Yan, Zhongzhong;Liu, Aiping;Ou, Yingcan;Li, Jianming;Yi, Haibo;...

通讯作者：

Liu, Weidong;Hu, Aixi

作者机构：

[Yan, Zhongzhong; Liu, WD; Hu, Aixi; Yi, Haibo] Hunan Univ, Coll Chem & Chem Engn, 1 Lushan Rd, Changsha 410082, Hunan, Peoples R China.

[Huang, Lu; Liu, Weidong; Li, Jianming; Liu, Minhua; Liu, Aiping; Yan, Zhongzhong; Ren, Jianwei; Zhang, Ning] Hunan Res Inst Chem Ind, Natl Engn Res Ctr Agrochem, Changsha 410007, Hunan, Peoples R China.

[Huang, Lu; Liu, Weidong; Li, Jianming; Liu, Minhua; Liu, Aiping; Ren, Jianwei] Hunan Prov Key Lab Agrochem, Changsha 410014, Hunan, Peoples R China.

[Ou, Yingcan] Hunan Univ Chinese Med, Schooll Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liu, WD; Hu, AX] H

Hunan Univ, Coll Chem & Chem Engn, 1 Lushan Rd, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

Antifungal activities;DFT calculation;Diflumetorim;Puccinia sorghi;Pyrimidinamine

期刊：

Bioorganic & Medicinal Chemistry

ISSN：

0968-0896

年：

2019

卷：

期：

页码：

3218-3228

DOI：

10.1016/j.bmc.2019.05.029

基金类别：

The authors extend their appreciation to the support of the National Natural Science Foundation of China (Grant 21572050 ).

机构署名：

本校为其他机构

摘要：

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optim...

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Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

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