Elucidating the role of KCTD10 in coronary atherosclerosis: Harnessing bioinformatics and machine learning to advance understanding

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成果类型：

期刊论文

作者：

Hu, Xiaomei;Liang, Fanqi;Zheng, Man;Xie, Juying*;Wang, Shanxi

通讯作者：

Xie, Juying;Wang, SX

作者机构：

[Xie, Juying; Wang, SX; Hu, Xiaomei; Wang, Shanxi] Xiangnan Univ, Coll Med Imaging Lab & Rehabil, Chenzhou 423000, Hunan, Peoples R China.

[Xie, Juying; Wang, SX; Hu, Xiaomei; Wang, Shanxi] Xiangnan Univ, Rehabil Dept, Affiliated Hosp, 25 Peoples West Rd, Chenzhou 423000, Hunan, Peoples R China.

[Liang, Fanqi] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.

[Zheng, Man] Dongying Peoples Hosp, Dongying Hosp, Shandong Prov Hosp Grp, Dongying 257091, Shandong, Peoples R China.

通讯机构：

[Xie, JY; Wang, SX ] X

Xiangnan Univ, Coll Med Imaging Lab & Rehabil, Chenzhou 423000, Hunan, Peoples R China.

Xiangnan Univ, Rehabil Dept, Affiliated Hosp, 25 Peoples West Rd, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

Coronary Atherosclerosis (AS);KCTD10;Lasso regression;SVM-RFE;Autoimmune inflammatory disorder

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2025

卷：

期：

页码：

8168

DOI：

10.1038/s41598-025-91376-3

基金类别：

Hunan Graduate Research Innovation Program [CX20230818]; Xiangnan University First-class Undergraduate Program Reform Project [2021-11]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Atherosclerosis (AS) is increasingly recognized as a chronic inflammatory disease that significantly compromises vascular health and serves as a major contributor to cardiovascular diseases. KCTD10, a protein implicated in a variety of biological processes, has garnered significant attention for its role in cardiovascular diseases and metabolic regulation. As a member of the KCTD protein family, KCTD10 is characterized by the presence of a T1 domain that interacts with voltage-gated potassium channels, a critical interaction for modulating chan...

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Elucidating the role of KCTD10 in coronary atherosclerosis: Harnessing bioinformatics and machine learning to advance understanding

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