Objective: The relationship between mobile phone use and anxiety and depression and its influencing factors were investigated by meta-analysis. Methods: Multiple databases are retrieved through the system, 42 literatures that met the standards were included, with a total of 60 independent effect quantities, The total sample size was 26871. Comprehensive meta-analysis V2.0 was used for the overall effect analysis and moderating effect test. Results: There was a significant positive correlation between mobile phone use and anxiety(r =0.21,P