Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways.

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成果类型：

期刊论文

作者：

Gao, Yan;Li, Juntong;Chu, Shifeng;Zhang, Zhao;Chen, Naihong;...

通讯作者：

Li, Lin;Zhang, Lan

作者机构：

[Li, L; Zhang, L; Li, Lin; Zhang, Lan; Gao, Yan] Capital Med Univ, Dept Pharm, Xuanwu Hosp, Beijing 100053, Peoples R China.

[Gao, Yan; Chen, Naihong; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Gao, Yan] China Med Univ, Sch Pharm, Dept Neuroendocrine Pharmacol, Shenyang North New Area, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.

[Li, Juntong] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Guangzhou 510405, Guangdong, Peoples R China.

[Chen, Naihong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Li, L; Zhang, L] C

Capital Med Univ, Dept Pharm, Xuanwu Hosp, Beijing 100053, Peoples R China.

语种：

英文

关键词：

Ginsenoside Rg1;Keap1/Nrf2/HO-1 pathway;NLRP3;T1DM

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2020

卷：

866

页码：

172801

DOI：

10.1016/j.ejphar.2019.172801

基金类别：

National Natural Science Foundation of China of ChinaNational Natural Science Foundation of China [81874351, 81873026, 81473373, 81730096, 81603316, U1402221]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; PUMC Graduate Education and Teaching Reform Project [10023201600801]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Ginseng has been traditionally used to treat diabetes mellitus (DM) in China. Ginsenoside Rg1 is a major active ingredient in processed ginseng, which elicits proven biological and pharmacological effects. Although a correlation between nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and predisposition to type 1 diabetes mellitus (T1DM) has been identified, the mechanism underlying the potential function and activation of NLRP3 inflammasome in DM have not been elucidated to date. The present study aimed to elucidate the effects and underlying mechanism of Rg1 on strep...

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Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways.

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