This work was supported by the National Natural Science Foundation of China (82074046, 82004184); the Science and Technology Innovation Program of Hunan Province (2023RC3166); the Natural Science Foundation of Hunan Province for Excellent Youth Project (2023JJ20033); The Hunan provincial “Shennong talent” project; Provincial Discipline Construction Project of Hunan University of Traditional Chinese Medicine (Integrated Traditional Chinese and Western Medicine). CRediT authorship contribution statement Rongsiqing Luo: Data curation, Methodology, Validation, Writing – original draft. Chunxiang He: Data curation, Writing – original draft. Jiawei He: Software, Validation, Visualization. Ze Li: Formal analysis, Methodology, Software. Yuke Wang: Formal analysis, Investigation, Methodology. Mirong Hou: Conceptualization, Formal analysis, Visualization. Ping Li: Validation, Visualization. Wenjing Yu: Data curation, Validation. Shaowu Cheng: acquisition, Methodology, Supervision, Writing – Acknowledgements R.S.Q.L., C.X.H., Z.Y.S., Z.L., Y.K.W., M.R.H., W.J.Y., and S.W.C. carried out the research. R.S.Q.L. and C.X.H. performed all the experiments and prepared the manuscripts. S.W.C. and Z.Y.S. provided funding and revised the manuscript. J.W.H assisted with visualization editing and language polishing. P.L. assisted with the pathological morphology experiment, and Z.L, Y.K.W. and M.R.H. collected the data and consulted on statistical analysis. Finally, all authors approved the manuscript.
