期刊论文

Li, XP

英文

International Immunopharmacology

1567-5769

2023

124

Pt A

110839

10.1016/j.intimp.2023.110839

Conclusions In summary, immunization surveillance of COVID-19 patients is necessary. The novel immunosurveillance indicator NK-MM correlates with COVID-19 severity and predicts clinical outcomes and short-term mortality. Future research could focus on elucidating the mechanisms by which COVID-19 causes changes in the mitochondrial mass of NK cells and provide a stronger basis for organelle-targeted therapy of NK cells. Fundings. This work was supported by the National Natural Science Foundation of China CRediT authorship contribution statement Bingqi Wang: Conceptualization, Methodology, Validation, Formal analysis, Data curation, Writing – original draft, Visualization. Zhenni Chen: Conceptualization, Methodology, Validation, Software, Data curation, Writing – original draft, Visualization. Yiran Huang: Conceptualization, Methodology, Formal analysis. Jiayi Ding: Software, Visualization. Yingrui Lin: Software, Visualization. Min Wang: Writing – review & editing, Resources. Xianping Li: Conceptualization, acquisition, Writing

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BACKGROUND: Severe SARS-CoV-2 infection results in lymphopenia and impaired function of T, B, and NK (TBNK-dominant) lymphocytes. Mitochondria are essential targets of SARS-CoV-2 and the efficacy of lymphocyte mitochondrial function for immunosurveillance in COVID-19 patients has not been evaluated. METHODS: Multi-parametric flow cytometry was used to characterize mitochondrial function, including mitochondrial mass (MM) and low mitochondrial membrane potential (MMP(low)), in TBNK-dominant lymphocytes from severe (n=93) and moderate (n=77) hospitalized COVID-19 patients. We compared the role o...