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Mesenchymal Stem Cell-Derived Microparticles: A Promising Therapeutic Strategy

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成果类型:
期刊论文
作者:
Tan, Xi;Gong, Yong-Zhen;Wu, Ping;Liao, Duan-Fang*;Zheng, Xi-Long
通讯作者:
Liao, Duan-Fang
作者机构:
[Tan, Xi; Zheng, Xi-Long; Wu, Ping; Gong, Yong-Zhen; Liao, Duan-Fang] Hunan Univ Tradit Chinese Med, Coll Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.
[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Smooth Muscle Res Grp, Calgary, AB T2N 4N1, Canada.
[Gong, Yong-Zhen] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China.
通讯机构:
[Liao, Duan-Fang] H
Hunan Univ Tradit Chinese Med, Coll Med, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
mesenchymal stem cells;microparticles;intercellular communication;clinical therapy
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2014
卷:
15
期:
8
页码:
14348-14363
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371161, 81173047]; Natural Science Foundation of HunanNatural Science Foundation of Hunan Province [12JJ5068]; Postgraduate Technology Innovation Project of Hunan [CX2014B366]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学院
摘要:
Mesenchymal stem cells (MSCs) are multipotent stem cells that give rise to various cell types of the mesodermal germ layer. Because of their unique ability to home in on injured and cancerous tissues, MSCs are of great potential in regenerative medicine. MSCs also contribute to reparative processes in different pathological conditions, including cardiovascular diseases and cancer. However, many studies have shown that only a small proportion of transplanted MSCs can actually survive and be incorporated into host tissues. The effects of MSCs cannot be fully explained by their number. Recent dis...

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